Automatic Particle Selection for Single Particle Analysis
Single Particle Analysis (SPA) is the problem of creating a three dimensional reconstruction of a molecular structure, e.g. a protein complex, starting from two dimensional images acquired through transmission electron microscopy. An important sub-problem of SPA is particle selection, or "boxing", which consists in localizing and identifying two dimensional projections of the structure in the original micrographs.
Particle selection is one of the main practical bottlenecks of SPA, because of the inherent high level of noise in electron microscopy images and the large number of particles (typically above 100.000) that are necessary to obtain high resolution reconstructions. Therefore, automating particle selection has recently become an active research area in biological image analysis.
ResourcesIn order to promote research on automated particle selection for Single Particle Analysis, we are making available the complete resources from our JSB paper below:
If you use the resources in this page, please cite our paper:
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