Fully-Integrated Wearable Sensor Arrays for Multiplexed In Situ Perspiration Analysis

Ali Javey, Wei Gao, Sam Emaminejad and Hnin Y.Y. Nyein

Berkeley Sensor and Actuator Center

Wearable sensor technologies play a significant role in realizing personalized medicine through continuously monitoring an individual’s health state. Human sweat is an excellent candidate for non-invasive monitoring as it contains physiologically rich information. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and full system integration to ensure the accuracy of measurements is a necessity. A mechanically flexible and fully-integrated perspiration analysis system is developed simultaneously and selectively measures sweat metabolites (e.g. glucose and lactate) and electrolytes (e.g. sodium and potassium ions), as well as the skin temperature to calibrate the sensors' response. The work bridges the technological gap between signal transduction, conditioning, processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin, and silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This wearable system can be used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and infer real-time assessment of the physiological state of the subjects. The platform enables a wide range of personalized diagnostic and physiological monitoring applications.

More information: https://www-bsac.eecs.berkeley.edu/project/zoom.php?urlmyprojectID=BPN818&URLnode=3