Rising Stars 2020:

Yi Xue

Postdoctoral Researcher

University of California, Berkeley

PhD '19 Massachusetts Institute of Technology

Areas of Interest

  • Biosystems and Computational Biology
  • Physical Electronics
  • Signal Processing
  • Optics
  • Computational Imaging


Three-dimensional Multi-site Random Access Photostimulation (3D-MAP)


Optical control of neural ensemble activity is crucial for understanding brain function and disease, yet no technology can achieve optogenetic control of very large numbers of neurons at extremely fast rates over a large volume. State-of-the-art multiphoton holographic optogenetics requires high power illumination that only addresses relatively small populations of neurons in parallel. Conversely, one-photon holographic techniques can stimulate more neurons, but with a trade-off between resolution and addressable volume. We introduce a new one-photon light sculpting technique, Three-Dimensional Multi-site random Access Photostimulation (3D-MAP), that simultaneously overcomes all these limitations by dynamically modulating light in both the spatial and angular domain at multi-kHz rates. Electrophysiological measurements confirm that 3D-MAP achieves near single-cell resolution in vitro and in vivo. Using 3D-MAP, we then interrogate neural circuits with 3D multi-site illumination with high resolution over a larger volume of intact brain than existing techniques.


I am a postdoctoral scholar in Prof. Laura Waller's group, Dept. of EECS, UC Berkeley. My research projects focus on the interdisciplinary field that draws from optics and neuroscience. My current project is to design optical microscopy along with computational techniques for optogenetic control and fluorescence imaging. I completed my PhD and master’s degree in Mechanical Engineering at MIT, and my bachelor’s degree in Optical Engineering at Zhejiang University, China.

Personal home page