[an error occurred while processing this directive] [an error occurred while processing this directive] [an error occurred while processing this directive] [an error occurred while processing this directive] Postdoctoral Researcher [an error occurred while processing this directive] University of California, Berkeley [an error occurred while processing this directive] PhD '19 Massachusetts Institute of Technology [an error occurred while processing this directive] [an error occurred while processing this directive] [an error occurred while processing this directive]

Biosystems and Computational Biology

Physical Electronics

Signal Processing

Optics

Computational Imaging

[an error occurred while processing this directive] Three-dimensional Multi-site Random Access Photostimulation (3D-MAP) [an error occurred while processing this directive] Optical control of neural ensemble activity is crucial for understanding brain function and disease, yet no technology can achieve optogenetic control of very large numbers of neurons at extremely fast rates over a large volume. State-of-the-art multiphoton holographic optogenetics requires high power illumination that only addresses relatively small populations of neurons in parallel. Conversely, one-photon holographic techniques can stimulate more neurons, but with a trade-off between resolution and addressable volume. We introduce a new one-photon light sculpting technique, Three-Dimensional Multi-site random Access Photostimulation (3D-MAP), that simultaneously overcomes all these limitations by dynamically modulating light in both the spatial and angular domain at multi-kHz rates. Electrophysiological measurements confirm that 3D-MAP achieves near single-cell resolution in vitro and in vivo. Using 3D-MAP, we then interrogate neural circuits with 3D multi-site illumination with high resolution over a larger volume of intact brain than existing techniques. [an error occurred while processing this directive] I am a postdoctoral scholar in Prof. Laura Waller's group, Dept. of EECS, UC Berkeley. My research projects focus on the interdisciplinary field that draws from optics and neuroscience. My current project is to design optical microscopy along with computational techniques for optogenetic control and fluorescence imaging. I completed my PhD and master’s degree in Mechanical Engineering at MIT, and my bachelor’s degree in Optical Engineering at Zhejiang University, China. [an error occurred while processing this directive] Personal home page [an error occurred while processing this directive] [an error occurred while processing this directive]